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Published, Version of Record (VoR)CC BY-NC-ND V4.0, Open
Journal article
Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat
Neuroscience letters, v 231(3), pp 135-138
1997
PMID: 9300640
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Abstract
We evaluated the therapeutic effects of remacemide hydrochloride, an
N-methyl-
d-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (
P<0.05), measured at 48 h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24 h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm.
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Details
- Title
- Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat
- Creators
- Douglas H SmithBrian R PerriRamesh RaghupathiKathryn E SaatmanTracy K McIntosh
- Publication Details
- Neuroscience letters, v 231(3), pp 135-138
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1997XU42200004
- Scopus ID
- 2-s2.0-0030847455
- Other Identifier
- 991014877833304721
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- Web of Science research areas
- Neurosciences