Journal article
Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders
Neuron (Cambridge, Mass.), v 78(6), pp 957-969
19 Jun 2013
PMID: 23791192
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Epigenetic reprogramming of adult human somatic cells to alternative fates, such as the conversion of human skin fibroblasts to induced pluripotency stem cells (iPSC), has enabled the generation of novel cellular models of CNS disorders. Cell reprogramming models appear particularly promising in the context of human neurological disorders of aging such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), for which animal models may not recapitulate key aspects of disease pathology. In addition, recent developments in reprogramming technology have allowed for more selective cell fate interconversion events, as from skin fibroblasts directly to diverse induced neuron (iN) subtypes. Challenges to human reprogramming-based cell models of disease are the heterogeneity of the human population and the extended temporal course of these disorders. A major goal is the accurate modeling of common nonfamilial "sporadic" forms of brain disorders.
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Details
- Title
- Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders
- Creators
- Liang Qiang - Columbia UniversityRyousuke Fujita - Departments of Pathology, Cell Biology, and Neurology and Taub Institute, Columbia University, Black Building 1208, 650 West 168th Street, New York, NY 10032, USAAsa Abeliovich - Departments of Pathology, Cell Biology, and Neurology and Taub Institute, Columbia University, Black Building 1208, 650 West 168th Street, New York, NY 10032, USA
- Publication Details
- Neuron (Cambridge, Mass.), v 78(6), pp 957-969
- Publisher
- Elsevier
- Number of pages
- 13
- Grant note
- NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) NIA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000321026900004
- Scopus ID
- 2-s2.0-84879255268
- Other Identifier
- 991019201496104721
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- Web of Science research areas
- Neurosciences