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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Renal Injury in All-Comers After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis
Curēus (Palo Alto, CA), v 12(5), pp e7985-e7985
06 May 2020
PMID: 32523841
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background
Acute kidney injury (AKI) following aortic valve replacement is associated with poor prognosis. Transcatheter aortic valve replacement (TAVR) is a novel strategy with a percutaneous approach and early recovery time. We conducted this meta-analysis to compare TAVR to surgical aortic valve replacement (SAVR) and their respective renal outcomes.
Methods
We searched for randomized controlled trials (RCTs) using MEDLINE, PUBMED, and Google Scholar databases from their inception till April 6, 2019, and included eight trials comparing TAVR to SAVR in cases that reported AKIs.
Results
We found a significant reduction in AKI after TAVR compared to SAVR at 30 days [n = 66 vs. n = 160, respectively; odds ratio (OR) = 0.38, 95% confidence interval (CI) = 0.28-0.51; p: <0.00001, I
2
= 0%]. At one year, a trend towards reduced renal failure was noted in the TAVR arm compared to the SAVR arm (n = 74 vs. n = 129, respectively; OR = 0.57, 95% CI = 0.32-1.01; p = 0.05, I
2
= 69%).
Conclusion
Based on our findings and analysis, we have concluded that TAVR is associated with significantly reduced renal injury at 30 days when compared to SAVR.
Metrics
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Details
- Title
- Renal Injury in All-Comers After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis
- Creators
- Waqas J Siddiqui - Drexel UniversityMurrium I Sadaf - Yale UniversityMuhammad Zain - Shaikh Zayed Medical College and HospitalRabia Mazhar - Ark Medical CenterRamla Abbas - Ark Medical CenterMohammad H Khan - Ark Medical CenterFaiza Ahmed - Medicine, Wynford Chelation Center, Toronto, CAN.Omer Zuberi - Ark Medical CenterYoussef M Al-Saghir - Ark Medical CenterJesse Goldman - Thomas Jefferson UniversitySandeep Aggarwal - University of Pennsylvania
- Publication Details
- Curēus (Palo Alto, CA), v 12(5), pp e7985-e7985
- Publisher
- Cureus
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nephrology (and Hypertension); Cardiology
- Web of Science ID
- WOS:000530650700003
- Other Identifier
- 991019169628204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems