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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Repeated Measures of Cervicovaginal Cytokines during Healthy Pregnancy: Understanding "Normal" Inflammation to Inform Future Screening
American journal of perinatology, v 37(6), pp 613-620
01 May 2020
PMID: 30978743
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective This study aimed to describe characteristics of cervicovaginal cytokines obtained during pregnancy from women who subsequently delivered at term.
Study Design We used repeated measures of 20 cervicovaginal cytokines, collected on average on a monthly basis, from the second to the ninth month of gestation among 181 term pregnancies in the Mexico City Pregnancy Research on Inflammation, Nutrition, & City Environment: Systematic Analyses cohort (2009-2014). Cytokines were quantified using multiplex assay.
Results Cytokine distributions differed more between than within cytokines. Across trimesters, cytokines interleukin (IL)-1Ra, IL-1 alpha, and IL-8 consistently had high concentrations compared with other measured cytokines. Cytokine intraclass correlation coefficients ranged from 0.41 to 0.82. Spearman's correlation coefficients among cytokine pairs varied but correlation directions were stable; 95.3% of the 190 correlation pairs remained either negative or positive across trimesters. Mean longitudinal patterns of log-transformed cytokines from Tobit regression varied across but less within cytokines.
Conclusion Although mean concentrations of cervicovaginal cytokines among term pregnancies were high, they were largely stable over time. The high cytokine concentrations corroborate that pregnancy is associated with an active inflammatory state. These characterizations may serve as a baseline for comparison to other obstetric outcomes, which may be helpful in understanding deviations from normal gestational inflammation.
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Details
- Title
- Repeated Measures of Cervicovaginal Cytokines during Healthy Pregnancy: Understanding "Normal" Inflammation to Inform Future Screening
- Creators
- Miatta A. Buxton - University of MichiganNoemi Meraz-Cruz - Universidad Nacional Autónoma de MéxicoBrisa N. Sanchez - University of MichiganBetsy Foxman - University of MichiganCarina J. Gronlund - University of MichiganJorge Beltran-Montoya - Universidad Nacional Autónoma de MéxicoMarisol Castillo-Castrejon - University of MichiganMarie S. O'Neill - University of MichiganFelipe Vadillo-Ortega - University of Michigan
- Publication Details
- American journal of perinatology, v 37(6), pp 613-620
- Publisher
- Thieme Medical Publishers
- Number of pages
- 8
- Grant note
- Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA T42 OH008455-09 / National Institute for Occupational Safety and Health; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) R25GM058641 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) P30 ES017885; R01 ES016932; R01 ES017022; T32 ES007062 / National Institute for Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) U.S. Department of Health andHuman Services Horace H. Rackham School of Graduate Studies, University of Michigan; University of Michigan System National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R25GM058641-18 / National Institute of General Medical Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) T42OH008455 / NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) P30ES017885 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000529912700009
- Scopus ID
- 2-s2.0-85084103924
- Other Identifier
- 991020100088604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics