Journal article
Repeated Reserpine Increases Striatal Dopamine Receptor and Guanine Nucleotide Binding Protein RNA
Journal of neurochemistry, v 60(2), pp 566-571
Feb 1993
PMID: 8419537
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
: In the present study the effects of repeated administration of reserpine on striatal dopamine receptor and guanine nucleotide binding protein mRNAs were determined. Twenty‐four hours after seven consecutive daily injections of reserpine—a treatment that is known to produce functional sensitization of D1 and D2 dopamine receptors—the level of striatal D1 dopamine receptor mRNA was unchanged. However, the level of mRNA for the G protein Gsα was increased by 127%. After extended reserpine treatment for 14 days, levels of both striatal D1 DA receptor and Gsα mRNAs were elevated by 99 and 78%, respectively. Seven days of reserpine treatment also increased levels of mRNA of the striatal D2 dopamine receptor and of G proteins Gi2α and Goα by 200, 79, and 32%, respectively. After 14 days of reserpine treatment the level of striatal D2 dopamine receptor mRNA was increased by twofold. In contrast, levels of the mRNAs coding for the G proteins Gi2α and Goα were unchanged. These data suggest that dopamine receptors and their respective G proteins play important roles in the development of sensitization of striatal dopamine receptors during repeated reserpine treatment. Furthermore, the persistent increase in level of striatal Gsα mRNA suggests that this G protein is necessary to maintain supersensitivity of the striatal D1 dopamine receptor system following long‐term dopamine depletion.
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Details
- Title
- Repeated Reserpine Increases Striatal Dopamine Receptor and Guanine Nucleotide Binding Protein RNA
- Creators
- Paul Butkerait - Drexel UniversityEitan Friedman - Drexel University
- Publication Details
- Journal of neurochemistry, v 60(2), pp 566-571
- Publisher
- Blackwell Publishing Ltd
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1993KG67100022
- Scopus ID
- 2-s2.0-0027397456
- Other Identifier
- 991019184039904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences