Journal article
Repeating Spatial Activations in Human Entorhinal Cortex
Current biology, v 25(8), pp 1080-1085
20 Apr 2015
PMID: 25843029
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ability to remember and navigate spatial environments is critical for everyday life. A primary mechanism by which the brain represents space is through hippocampal place cells, which indicate when an animal is at a particular location [1]. An important issue is understanding how the hippocampal place-cell network represents specific properties of the environment, such as signifying that a particular position is near a doorway or that another position is near the end of a corridor. The entorhinal cortex (EC), as the main input to the hippocampus, may play a key role in coding these properties because it contains neurons that activate at multiple related positions per environment [2-6]. We examined the diversity of spatial coding across the human medial temporal lobe by recording neuronal activity during virtual navigation of an environment containing four similar paths. Neurosurgical patients performed this task as we recorded from implanted microelectrodes, allowing us to compare the human neuronal representation of space with that of animals. EC neurons activated in a repeating manner across the environment, with individual cells spiking at the same relative location across multiple paths. This finding indicates that EC cells represent non-specific information about location relative to an environment's geometry, unlike hippocampal place cells, which activate at particular random locations. Given that spatial navigation is considered to be a model of how the brain supports non-spatial episodic memory [7-10], these findings suggest that EC neuronal activity is used by the hippocampus to represent the properties of different memory episodes [2, 11].
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Details
- Title
- Repeating Spatial Activations in Human Entorhinal Cortex
- Creators
- Jonathan F. Miller - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USAItzhak Fried - Semel Institute for Neuroscience and Human BehaviorNanthia Suthana - Semel Institute for Neuroscience and Human BehaviorJoshua Jacobs - Columbia UniversityJana Jacobs - Electrical and Computer Engineering
- Publication Details
- Current biology, v 25(8), pp 1080-1085
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- R01MH061975 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01NS084017 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Brain and Behavior Research Foundation MH061975 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:000353351900030
- Scopus ID
- 2-s2.0-84928771667
- Other Identifier
- 991019173999404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biology
- Cell Biology