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Journal article
Repetitive element transcript accumulation is associated with inflammaging in humans
GeroScience
20 Apr 2024
PMID: 38641753
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healthspan. Growing evidence suggests that transcripts from repetitive elements (RE) in the genome contribute to this "inflammaging" by stimulating innate immune activation, but evidence of RE-associated inflammation with aging in humans is limited. Here, we present transcriptomic and clinical data showing that RE transcript levels are positively related to gene expression of innate immune sensors, and to serum interleukin 6 (a marker of systemic inflammation), in a large group of middle-aged and older adults. We also: (1) use transcriptomics and whole-genome bisulfite (methylation) sequencing to show that many RE may be hypomethylated with aging, and that aerobic exercise, a healthspan-extending intervention, reduces RE transcript levels and increases RE methylation in older adults; and (2) extend our findings in a secondary dataset demonstrating age-related changes in RE chromatin accessibility. Collectively, our data support the idea that age-related RE transcript accumulation may play a role in inflammaging in humans, and that RE dysregulation with aging may be due in part to upstream epigenetic changes.
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Details
- Title
- Repetitive element transcript accumulation is associated with inflammaging in humans
- Creators
- Meghan E. Smith - Colorado State UniversityDevin Wahl - Colorado State UniversityAlyssa N. Cavalier - Colorado State UniversityGabriella T. Mcwilliams - Colorado State UniversityMatthew J. Rossman - University of Colorado BoulderGregory R. Giordano - University of Colorado BoulderAngela D. Bryan - University of Colorado BoulderDouglas R. Seals - University of Colorado BoulderThomas J. Larocca - Colorado State University
- Publication Details
- GeroScience
- Publisher
- Springer Nature
- Number of pages
- 17
- Grant note
- National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Sciences
- Web of Science ID
- WOS:001205246500001
- Scopus ID
- 2-s2.0-85190802992
- Other Identifier
- 991021894713004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology