Journal article
Replicase Genes of Murine Coronavirus Strains A59 and JHM Are Interchangeable: Differences in Pathogenesis Map to the 3′ One-Third of the Genome
Journal of virology, v 81(2), pp 1022-1026
Jan 2007
PMID: 17079303
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Abstract
The important roles of the spike protein and other structural proteins in murine coronavirus (MHV) pathogenesis have been demonstrated; however, the role of the replicase gene remains unexplored. We assessed the influence of the replicase genes of the highly neurovirulent MHV-JHM strain and the hepatotropic and mildly neurovirulent A59 strain in acute infection of the mouse. Analysis of chimeric A59/JHM recombinant viruses indicates that the replicase genes are interchangeable and that it is the 3′ end of the genome, encoding the structural proteins, rather than the replicase gene, that determines the pathogenic properties of these chimeras.
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Details
- Title
- Replicase Genes of Murine Coronavirus Strains A59 and JHM Are Interchangeable: Differences in Pathogenesis Map to the 3′ One-Third of the Genome
- Creators
- Sonia Navas-Martin - Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104Maarten Brom - Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104Ming-Ming Chua - Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104Richard Watson - Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104Zhaozhu Qiu - Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104Susan R Weiss - Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104
- Publication Details
- Journal of virology, v 81(2), pp 1022-1026
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000243350100057
- Scopus ID
- 2-s2.0-33846044238
- Other Identifier
- 991014878487404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology