Journal article
Replication of the Human Hepatitis Delta Virus Genome Is Initiated in Mouse Hepatocytes following Intravenous Injection of Naked DNA or RNA Sequences
Journal of virology, v 75(7), pp 3469-3473
01 Apr 2001
PMID: 11238873
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ABSTRACT
As early as 5 days after DNA copies of the hepatitis delta virus (HDV) genome or even
in vitro
-transcribed HDV RNA sequences were injected into the mouse tail vein using the hydrodynamics-based transfection procedure of F. Liu et al. (Gene Ther. 6:1258–1266, 1999), it was possible to detect in the liver by Northern analyses of RNA, immunoblots of protein, and immunostaining of liver sections what were considered typical features of HDV genome replication. This transfection strategy should have valuable applications for in vivo studies of HDV replication and pathogenesis and may also be useful for studies of other hepatotropic viruses.
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Details
- Title
- Replication of the Human Hepatitis Delta Virus Genome Is Initiated in Mouse Hepatocytes following Intravenous Injection of Naked DNA or RNA Sequences
- Creators
- Jinhong Chang - Fox Chase Cancer CenterLuis J. Sigal - Fox Chase Cancer CenterAnthony Lerro - Fox Chase Cancer CenterJohn Taylor - Fox Chase Cancer Center
- Publication Details
- Journal of virology, v 75(7), pp 3469-3473
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000167469600042
- Scopus ID
- 2-s2.0-0035107821
- Other Identifier
- 991020547612904721
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- Web of Science research areas
- Virology