Journal article
Replicative senescence: a critical review
Mechanisms of ageing and development, v 125(10), pp 827-848
01 Oct 2004
PMID: 15541776
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human cells in culture have a limited proliferative capacity. After a period of vigorous proliferation, the rate of cell division declines and a number of changes occur in the cells including increases in size, in secondary lysosomes and residual bodies, nuclear changes and a number of changes in gene expression which provide biomarkers for senescence. Although human cells in culture have been used for over 40 years as models for understanding the cellular basis of aging, the relationship of replicative senescence to aging of the organism is still not clear. In this review, we discuss replicative senescence in the light of current information on signal transduction and mitogenesis, cell stress, apoptosis, telomere changes and finally we discuss replicative senescence as a model of aging in vivo.
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Details
- Title
- Replicative senescence: a critical review
- Creators
- Vincent J. Cristofalo - Lankenau Institute for Medical ResearchAntonello Lorenzini - Lankenau Institute for Medical ResearchR.G. Allen - The Sally Balin Medical Center, Media, PA, USAClaudio Torres - Lankenau Institute for Medical ResearchMaria Tresini - Lankenau Institute for Medical Research
- Publication Details
- Mechanisms of ageing and development, v 125(10), pp 827-848
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000225614800017
- Scopus ID
- 2-s2.0-8444237425
- Other Identifier
- 991020836451104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology