Journal article
Reply Effects of progesterone or neuroactive steroid?
Nature (London), v 395(6703), pp 652-653
15 Oct 1998
Abstract
Smith et al. reply - Morrowet al.are incorrect to state that we did not provide direct evidence that 3α-OH-5α-pregnan-20-one (3α,5α-THP, or allopregnanolone) levels were reduced by indomethacin. We pointed out that our previous studies showed that indomethacin administration concomitant with progesterone reduced the level of 3α,5α-THP in the central nervous system from 8.2 6 1.3 ng per g to 2.3 0.35 ng per g without altering levels of 5α-DHP or progesterone. This treatment, which prevented the withdrawal of 3α,5α-THP that normally accompanies progesterone withdrawal, completely prevented the withdrawal effects of progesterone we observed, including acceleration in the decay of GABA-gated current and upregulation of the GABAA-receptor α4 subunit.
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Details
- Title
- Reply Effects of progesterone or neuroactive steroid?
- Creators
- Sheryl S Smith - Allegheny University of the Health SciencesQi Hua Gong - Allegheny University of the Health SciencesFu-Chun Hsu - Allegheny University of the Health SciencesRonald S Markowitz - Allegheny University of the Health SciencesJ. M. H ffrench-Mullen - Wilmington UniversityXinshe Li - Allegheny University of the Health SciencesSusan S Smith - [Retired Faculty]
- Publication Details
- Nature (London), v 395(6703), pp 652-653
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000076472600033
- Other Identifier
- 991019167449804721
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- Web of Science research areas
- Multidisciplinary Sciences