Journal article
Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis
Cell cycle (Georgetown, Tex.), v 11(12), pp 2348-2358
15 Jun 2012
PMID: 22672904
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The aberrantly increased lipogenesis is a universal metabolic feature of proliferating tumor cells. Although most normal cells acquire the bulk of their fatty acids from circulation, tumor cells synthesize more than 90% of required lipids de novo. The sterol regulatory element-binding protein 1 (SREBP1), encoded by
SREBF1
gene, is a master regulator of lipogenic gene expression. SREBP1 and its target genes are overexpressed in a variety of cancers; however, the role of SREBP1 in endometrial cancer is largely unknown. We have screened a cohort of endometrial cancer (EC) specimen for their lipogenic gene expression and observed a significant increase of SREBP1 target gene expression in cancer cells compared with normal endometrium. By using immunohistochemical staining, we confirmed SREBP1 protein overexpression and demonstrated increased nuclear distribution of SREBP1 in EC. In addition, we found that knockdown of SREBP1 expression in EC cells suppressed cell growth, reduced colonigenic capacity and slowed tumor growth in vivo. Furthermore, we observed that knockdown of SREBP1 induced significant cell death in cultured EC cells. Taken together, our results show that SREBP1 is essential for EC cell growth both in vitro and in vivo, suggesting that SREBP1 activity may be a novel therapeutic target for endometrial cancers.
Metrics
Details
- Title
- Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis
- Creators
- Weihua Li - Qilu Hospital of Shandong UniversityYanhong Tai - Fourth People’s Hospital of JinanJie Zhou - Thomas Jefferson UniversityWeiting Gu - Thomas Jefferson UniversityZhaofang BaiTao Zhou - National Center of Biomedical AnalysisZhijiu Zhong - Thomas Jefferson UniversityPeter A. McCue - Thomas Jefferson University HospitalNianli Sang - Florida State UniversityJun-Yuan Ji - Texas A&M Health Science CenterBeihua Kong - Qilu Hospital of Shandong UniversityJie Jiang - Qilu Hospital of Shandong UniversityChenguang Wang - Thomas Jefferson University
- Publication Details
- Cell cycle (Georgetown, Tex.), v 11(12), pp 2348-2358
- Publisher
- Landes Bioscience
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000305353000023
- Scopus ID
- 2-s2.0-84862837453
- Other Identifier
- 991019167991404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology