Journal article
Reproduction Differentially Affects Trabecular Bone Depending on Its Mechanical Versus Metabolic Role
Journal of biomechanical engineering, v 139(11), pp 1110061-11100610
01 Nov 2017
PMID: 28979992
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
During pregnancy and lactation, the maternal skeleton provides calcium for fetal/infant growth, resulting in substantial bone loss, which partially recovers after weaning. However, the amount of bone that is lost and the extent of post-weaning recovery are highly variable among different skeletal sites, and, despite persistent alterations in bone structure at some locations, reproductive history does not increase postmenopausal fracture risk. To explain this phenomenon, we hypothesized that the degree of reproductive bone loss/recovery at trabecular sites may vary depending on the extent to which the trabecular compartment is involved in the bone's load-bearing function. Using a rat model, we quantified the proportion of the load carried by the trabeculae, as well as the extent of reproductive bone loss and recovery, at two distinct skeletal sites: the tibia and lumbar vertebra. Both sites underwent significant bone loss during pregnancy and lactation, which was partially recovered post-weaning. However, the extent of the deterioration and the resumption of trabecular load-bearing capacity after weaning varied substantially. Tibial trabecular bone, which bore a low proportion of the total applied load, underwent dramatic and irreversible microstructural deterioration during reproduction. Meanwhile, vertebral trabecular bone bore a greater fraction of the load, underwent minimal deterioration in microarchitecture, and resumed its full load-bearing capacity after weaning. Because pregnancy and lactation are physiological processes, the distinctive responses to these natural events among different skeletal sites may help to elucidate the extent of the trabecular bone's structural versus metabolic functions.
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Details
- Title
- Reproduction Differentially Affects Trabecular Bone Depending on Its Mechanical Versus Metabolic Role
- Creators
- Chantal M. J. de Bakker - University of PennsylvaniaWei-Ju Tseng - University of PennsylvaniaYihan Li - University of PennsylvaniaHongbo Zhao - Key Laboratory of Biorheological Science andTechnology,Ministry of Education and BioengineeringCollege,Chongqing University,Chongqing 400044, Chinae-mail:Allison R. Altman-Singles - Pennsylvania State UniversityYonghoon Jeong - Ohio State Univ, Coll Dent, Div Orthodont, Columbus, OH 43210 USAJuhanna Robberts - University of PennsylvaniaLin Han - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USADo-Gyoon Kim - The Ohio State UniversityX. Sherry Liu - University of Pennsylvania
- Publication Details
- Journal of biomechanical engineering, v 139(11), pp 1110061-11100610
- Publisher
- Asme
- Number of pages
- 10
- Grant note
- P30AR069619 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) 1653216 / National Science Foundation (NSF) (Division of Civil, Mechanical and Manufacturing Innovation) Penn Center for Musculoskeletal Disorders (PCMD) NIH/NIAMS P30-AR069619; NIH/NIAMS K01-AR066743; NIH/NIAMS R03-AR065145 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA AR06514; AR066743; AR069619 / National Institutes of Health (NIH) (National Institute of Arthritis and Musculoskeletal and Skin Diseases); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) CMMI-1653216 / National Science Foundation (NSF) National Science Foundation (NSF) (NSF Graduate Research Fellowship)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000413395300008
- Scopus ID
- 2-s2.0-85031502211
- Other Identifier
- 991019169904604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical