Abortion, Spontaneous - epidemiology Adult Aluminum - adverse effects Chi-Square Distribution Congenital Abnormalities - epidemiology Cross-Sectional Studies Female Humans Logistic Models Male Medical Laboratory Personnel - statistics & numerical data Metallurgy - manpower Multivariate Analysis Occupational Exposure - adverse effects Odds Ratio Pregnancy Pregnancy Outcome - epidemiology Premature Birth - epidemiology Sex Factors Time Factors
Several adverse pregnancy outcomes were reported among female laboratory workers in a North American aluminum smelter. To determine whether these outcomes were associated with any occupational exposure at the plant, a cross-sectional survey was undertaken.
Rates of miscarriage, premature singleton birth, and major congenital anomaly occurring during employment were compared with a reference group comprised of all pregnancies that occurred before employment.
Among female workers, the excess of congenital anomalies among female laboratory workers that defined the initial cluster was observed, but no specific pattern was found.
On the basis of these analyses, the increase in congenital anomalies could not be attributed to occupational exposures at the smelter nor could potential exposure likely explain the diverse anomalies described.