Journal article
Reserpine effects on body temperature in maturing mice
General pharmacology, v 13(1), 63
1982
PMID: 7060923
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
1.
1. The effects of a single dose of reserpine (1 mg/kg body wt) have been studied 1 hr and 24 hr after injection. Young mice were tested on days 3, 7, 10 and 14 after birth and compared with 6-week-old adults.
2.
2. Body temperature (
T
b) fell in reserpine-treated young animals 1 hr after injection, as compared with vehicle-treated littermate controls; however, the effect was small in 3- and 7-day animals when compared with 10- and 14-days.
3.
3.
T
b was significantly depressed in young reserpine-treated animals 24 hr after injection, with greater effects again found in the 10- and 14-day animals. In contrast, the adult animals failed to show an effect on
T
b at either 1 hr or 24 hr after injection.
4.
4. A second dose of reserpine 24 hr after the first dose was ineffective in producing further changes in
T
b in 3-, 7-, and 10-day animals; but in 14-day and adult animals the second dose produced a significant decrease in
T
b.
Metrics
Details
- Title
- Reserpine effects on body temperature in maturing mice
- Creators
- Cecilie Goodrich - Cleveland State University
- Publication Details
- General pharmacology, v 13(1), 63
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1982NC35800013
- Scopus ID
- 2-s2.0-0020082371
- Other Identifier
- 991021463607804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy