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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Respiration following spinal cord injury: Evidence for human neuroplasticity
Respiratory physiology & neurobiology, v 189(2), pp 450-464
01 Nov 2013
PMID: 23891679
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Respiratory dysfunction is one of the most devastating consequences of cervical spinal cord injury (SCI) with impaired breathing being a leading cause of morbidity and mortality in this population. However, there is mounting experimental and clinical evidence for moderate spontaneous respiratory recovery, or "plasticity", after some spinal cord injuries. Pre-clinical models of respiratory dysfunction following SCI have demonstrated plasticity at neural and behavioral levels that result in progressive recovery of function. Temporal changes in respiration after human SCI have revealed some functional improvements suggesting plasticity paralleling that seen in experimental models-a concept that has been previously under-appreciated. While the extent of spontaneous recovery remains limited, it is possible that enhancing or facilitating neuroplastic mechanisms may have significant therapeutic potential. The next generation of treatment strategies for SCI and related respiratory dysfunction should aim to optimize these recovery processes of the injured spinal cord for lasting functional restoration. (C) 2013 Elsevier B.V. All rights reserved.
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Details
- Title
- Respiration following spinal cord injury: Evidence for human neuroplasticity
- Creators
- Daniel J. Hoh - McKnight Brain InstituteLynne M. Mercier - McKnight Brain InstituteShaunn P. Hussey - McKnight Brain InstituteMichael A. Lane - McKnight Brain Institute
- Publication Details
- Respiratory physiology & neurobiology, v 189(2), pp 450-464
- Publisher
- Elsevier
- Number of pages
- 15
- Grant note
- R01NS081112 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01 NS081112-01 / National Institute of Health (NINDS); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000327110200028
- Scopus ID
- 2-s2.0-84886237026
- Other Identifier
- 991019168783304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physiology
- Respiratory System