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Journal article
Respiratory Training and Plasticity After Cervical Spinal Cord Injury
Frontiers in cellular neuroscience, v 15, pp 700821-700821
21 Sep 2021
PMID: 34621156
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which are life threatening, the majority of SCIs are anatomically incomplete. Spared neural pathways contribute to functional and anatomical neuroplasticity that can occur spontaneously, or can be harnessed using rehabilitative, electrophysiological, or pharmacological strategies. With a focus on respiratory networks that are affected by cervical level SCI, the present review summarizes how non-invasive respiratory treatments can be used to harness this neuroplastic potential and enhance long-term recovery. Specific attention is given to "respiratory training" strategies currently used clinically (e.g., strength training) and those being developed through pre-clinical and early clinical testing [e.g., intermittent chemical stimulation via altering inhaled oxygen (hypoxia) or carbon dioxide stimulation]. Consideration is also given to the effect of training on non-respiratory (e.g., locomotor) networks. This review highlights advances in this area of pre-clinical and translational research, with insight into future directions for enhancing plasticity and improving functional outcomes after SCI.
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Details
- Title
- Respiratory Training and Plasticity After Cervical Spinal Cord Injury
- Creators
- Margo Randelman - Drexel UniversityLyandysha V. Zholudeva - Gladstone InstitutesStephane Vinit - University of Paris-SaclayMichael A. Lane - Drexel University
- Publication Details
- Frontiers in cellular neuroscience, v 15, pp 700821-700821
- Publisher
- Frontiers Media Sa
- Number of pages
- 16
- Grant note
- INSERM; Institut National de la Sante et de la Recherche Medicale (Inserm); European Commission R01 NS104291 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Wings for Life Spinal Cord Research Foundation Universite de Versailles Saint-Quentin-en-Yvelines Fondation de France Fondation Medisite Lisa Dean Moseley Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000703462000001
- Scopus ID
- 2-s2.0-85116782980
- Other Identifier
- 991019168878204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences