Journal article
Respiratory medication use in extremely premature (< 29 weeks) infants during initial NICU hospitalization: Results from the prematurity and respiratory outcomes program
Pediatric pulmonology, v 55(2), pp 360-368
01 Feb 2020
PMID: 31794157
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background The use of medications to treat respiratory conditions of extreme prematurity is often based upon studies of adults or children over 2 years of age. Little is known about the spectrum of medications used or dosing ranges. To inform the design of future studies, we conducted a prospective analysis of respiratory medication exposure among 832 extremely low gestational age neonates. Methods The prematurity and respiratory outcomes program (PROP) enrolled neonates less than 29-week gestation from 6 centers incorporating 13 clinical sites. We collected recorded daily "respiratory" medications given along with dosing information through 40-week postmenstrual age or neonatal intensive care unit discharge if earlier. Results PROP participants were exposed to a wide range of respiratory medications, often at doses beyond published recommendations. Nearly 50% received caffeine and furosemide beyond published recommendations for cumulative dose. Those who developed bronchopulmonary dysplasia were more likely to receive treatment with respiratory medications. However, more than 30% of PROP subjects that did not develop bronchopulmonary dysplasia also were treated with diuretics, systemic steroids, and other respiratory medications. Conclusion Extremely preterm neonates in PROP were exposed to high doses of medications at levels known to generate significant adverse effects. With limited evidence for efficacy, there is an urgent need for controlled trials in this vulnerable patient population.
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Details
- Title
- Respiratory medication use in extremely premature (< 29 weeks) infants during initial NICU hospitalization: Results from the prematurity and respiratory outcomes program
- Creators
- James M. Greenberg - Cincinnati Children's Hospital Medical CenterBrenda B. Poindexter - Cincinnati Children's Hospital Medical CenterPamela A. Shaw - University of PennsylvaniaScarlett L. Bellamy - University of PennsylvaniaRoberta L. Keller - University of California, San FranciscoPaul E. Moore - Vanderbilt UniversityChristopher McPherson - Washington University in St. LouisRita M. Ryan - Medical University of South Carolina
- Publication Details
- Pediatric pulmonology, v 55(2), pp 360-368
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- U01 HL101456 / National Heart, Lung, and Blood Institute (Vanderbilt University) U01 HL101800 / National Heart, Lung, and Blood Institute (Cincinnati) 5R01HL105702 / National Heart, Lung, and Blood Institute (DukeIndiana) U01 HL101794 / Eunice Kennedy Shriver National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U01 HL101465 / National Heart, Lung, and Blood Institute (Washington University) DCC/BPCAU01 HL101794 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) U01 HL101798 / National Heart, Lung, and Blood Institute (University of California) U01 HL101813 / National Heart, Lung, and Blood Institute (Rochester-Buffalo )
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000500104600001
- Scopus ID
- 2-s2.0-85076294189
- Other Identifier
- 991019299000504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics
- Respiratory System