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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Respiratory neuroplasticity and cervical spinal cord injury: translational perspectives
Trends in neurosciences (Regular ed.), v 31(10), pp 538-547
01 Oct 2008
PMID: 18775573
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Paralysis of the diaphragm is a severe consequence of cervical spinal cord injury. This condition can be experimentally modeled by lateralized, high cervical lesions that interrupt descending inspiratory drive to the corresponding phrenic nucleus. Although partial recovery of ipsilateral diaphragm function occurs over time, recent findings show persisting chronic deficits in ventilation and phrenic motoneuron activity. Some evidence suggests, however, that spontaneous recovery can be enhanced by modulating neural pathways to phrenic motoneurons via synaptic circuitries which appear more complex than previously envisioned. The present review highlights these and other recent experimental multidisciplinary findings pertaining to respiratory neuroplasticity in the rat. Translational considerations are also emphasized, with specific attention directed at the clinical and interpretational strengths of different lesion models and outcome measures.
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Details
- Title
- Respiratory neuroplasticity and cervical spinal cord injury: translational perspectives
- Creators
- Michael A. Lane - McKnight Brain InstituteDavid D. Fuller - University of Florida College of Public Health and Health ProfessionsTodd E. White - McKnight Brain InstitutePaul J. Reier - McKnight Brain Institute
- Publication Details
- Trends in neurosciences (Regular ed.), v 31(10), pp 538-547
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- R01NS054025 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Craig H. Neilsen Postdoctoral Fellowship Anne and Oscar Lackner Endowed Chair RO1 NS054025 / NIH/NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000260703300006
- Scopus ID
- 2-s2.0-52049099117
- Other Identifier
- 991019298729504721
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- Web of Science research areas
- Neurosciences