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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Response inhibition among early adolescents prenatally exposed to tobacco: An fMRI study
Neurotoxicology and teratology, v 31(5), pp 283-290
01 Sep 2009
PMID: 19351556
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Children prenatally exposed to tobacco have been found to exhibit increased rates of behavior problems related to response inhibition deficits. The present study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a Go/No-Go response inhibition task using an event-related functional MRI (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, IQ, current environmental smoke exposure, and handedness were statistically controlled. Tobacco-exposed children showed greater activation in a relatively large and diverse set of regions, including left frontal, right occipital, and bilateral temporal and parietal regions. In contrast, unexposed but not exposed children showed activation in the cerebellum, which prior research has indicated is important for attention and motor preparation. The diversity of regions showing greater activation among tobacco-exposed children suggests that their brain function is characterized by an inefficient recruitment of regions required for response inhibition. (C) 2009 Elsevier Inc. All rights reserved.
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Details
- Title
- Response inhibition among early adolescents prenatally exposed to tobacco: An fMRI study
- Creators
- David S. Bennett - Drexel UniversityFeroze B. Mohamed - Temple UniversityDennis P. Carmody - Rutgers, The State University of New JerseyMargaret Bendersky - Rutgers, The State University of New JerseySunil Patel - Drexel UniversityMaryam Khorrami - Temple UniversityScott H. Faro - Temple UniversityMichael Lewis - Johnson University
- Publication Details
- Neurotoxicology and teratology, v 31(5), pp 283-290
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- DA07109; R01 DA007109-12; R01 DA007109 / NIDA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) R01DA007109 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000270700600003
- Scopus ID
- 2-s2.0-69549124034
- Other Identifier
- 991019169581704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Toxicology