Journal article
Response of aged mice to primary virus infections
Immunological reviews, v 205(1), pp 285-296
Jun 2005
PMID: 15882361
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aging is associated with an increased morbidity to virus infections as well as a delay in clearance of symptoms after infection. Studies of sublethal virus infections of aged mice closely mirror the human situation: there is a delay in clearance of virus. The delay in virus clearance is accompanied by a delay and a decrease in T-cell response, particularly of CD8(+) T cells. Intrinsic alterations of T cells of aged mice contribute to this decrease in virus-specific T-cell response; however, evidence suggests that environmental or innate components of the aged host also influence this age-associated decline in clearance of virus. While the changes in the adaptive immune response have been carefully described, the early events in the generation of the T-cell response after virus infection have received limited attention. Importantly, age-associated changes in the innate response to virus infection, particularly production of and response to interferon (IFN)-alpha/beta, cytotoxicity and IFN-gamma production by natural killer cells, interleukin-12 induction, and depletion of non-specific T cells early during virus infection need further evaluation.
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Details
- Title
- Response of aged mice to primary virus infections
- Creators
- Donna M Murasko - Department of Bioscience and Biotechnology, College of Arts and Sciences, Drexel University, Philadelphia, PA 19104, USA. donna.murasko@drexel.eduJiu Jiang
- Publication Details
- Immunological reviews, v 205(1), pp 285-296
- Publisher
- Wiley; England
- Grant note
- AG14913 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Biology
- Web of Science ID
- WOS:000228976300022
- Scopus ID
- 2-s2.0-20344396332
- Other Identifier
- 991014877898004721
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- Web of Science research areas
- Immunology