Journal article
Restraint stress applied prior to chemical sensitization modulates the development of allergic contact dermatitis differently than restraint prior to challenge
Journal of neuroimmunology, v 113(1), pp 72-80
2001
PMID: 11137578
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BALB/c mice were sensitized and challenged on the skin with the contact sensitizer, dinitroflourobenzene. Acute restraint applied before sensitization diminished, whereas restraint administered before challenge enhanced, chemical-induced ear swelling and leukocytic infiltration in the dermis. Administration of RU486, a glucocorticoid receptor antagonist, partially reversed restraint modulation of the ear swelling response in both restraint paradigms. Restraint did not modulate significantly the concentration of TNF-α and IL-1β in ear tissue homogenates. These data show that acute restraint modulates cutaneous sensitization differently than challenge, but the changes are not reflected in TNF-α or IL-lβ production.
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Details
- Title
- Restraint stress applied prior to chemical sensitization modulates the development of allergic contact dermatitis differently than restraint prior to challenge
- Creators
- Melanie S Flint - National Institute for Occupational Safety and HealthJohn M Valosen - MCP-Hahnemann School of Medicine, 2900 Queen Lane, Philadelphia, PA 19144, USAElizabeth A Johnson - National Institute for Occupational Safety and HealthDiane B Miller - National Institute for Occupational Safety and HealthSally S Tinkle - National Institute for Occupational Safety and HealthEbony A Johnson - Accelerated Career Entry Bachelor of Science in Nursing (BSN)
- Publication Details
- Journal of neuroimmunology, v 113(1), pp 72-80
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Accelerated Career Entry Bachelor of Science in Nursing (BSN)
- Web of Science ID
- WOS:000166575000008
- Scopus ID
- 2-s2.0-0035255069
- Other Identifier
- 991019168134504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Neurosciences