Journal article
Results of a double-blind placebo-controlled study of the double-stranded RNA drug polyI:PolyC12U in the treatment of HIV infection
European journal of clinical microbiology & infectious diseases, v 15(7), pp 580-587
01 Jul 1996
Abstract
In this multicenter, randomized, double-blind study the activity of polyI:polyC12U administered with zidovudine was evaluated in the treatment of HIV infection. Thirty-six HIV-positive, pre-AIDS individuals (100 - 500 CD4 + cells/mm 3) who had had at least six months of zidovudine therapy received polyI:polyC12U (400 or 700 mg) or placebo twice weekly with zidovudine. PolyI:polyC12U subjects with baseline CD4 + counts _> 300/mm 3 showed a trend towards reduced CD4 + loss versus placebo recipients. PolyI:polyC12U subjects were more likely to exhibit positive delayed-type hypersensitivity responses than placebo recipients. Placebo subjects crossing over to polyI:polyC12U therapy demonstrated improved CD4 + and delayed-type hypersensitivity responses. PolyI:polyC12U subjects with baseline CD4 + counts > 300/mm 3 were less likely to develop AIDS than similar placebo subjects. PolyI:polyC12U therapy of HIV-positive subjects restored or stabilized immune function as indexed by delayed-type hypersensitivity reactivity and, in individuals with CD4 + counts > 300/mm 3, abrogated CD4 + loss and reduced disease progression. PolyI:polyC12U was generally well-tolerated in this zidovudine-treated population. No subject discontinued therapy due to an adverse reaction or aberrant laboratory parameter.
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Details
- Title
- Results of a double-blind placebo-controlled study of the double-stranded RNA drug polyI:PolyC12U in the treatment of HIV infection
- Creators
- K A ThompsonD R Strayer - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)P D SalvatoC E ThompsonN. KlimasA. MolaviA K HamillZ ZhengD VenturaW A Carter
- Publication Details
- European journal of clinical microbiology & infectious diseases, v 15(7), pp 580-587
- Publisher
- Springer Nature
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Scopus ID
- 2-s2.0-9444284910
- Other Identifier
- 991021878011004721