Journal article
Retroviral proteomics and interactomes: intricate balances of cell survival and viral replication
Expert review of proteomics, v 5(3), pp 507-528
01 Jun 2008
PMID: 18532916
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Overall changes in the host cellular proteome upon retroviral infection intensify from the initial entry of the virus to the incorporation of viral DNA into the host genome, and finally to the consistent latent state of infection. The host cell reacts to both the entry of viral elements and the manipulation of host cellular machinery, resulting in a cascade of signaling events and pathway activation. Cell type- and tissue-specific responses are also characteristic of infection and can be classified based on the differential expression of genes and proteins between normal and disease states. The characterization of differentially expressed proteins upon infection is also critical in identifying potential biomarkers within infected bodily fluids. Biomarkers can be used to monitor the progression of infection, track the effectiveness of specific treatments and characterize the mechanisms of disease pathogenesis. Standard proteomic approaches have been applied to monitor the changes in global protein expression and localization in infected cells, tissues and fluids. Here we report on recent investigations into the characterization of proteomes in response to retroviral infection.
Metrics
Details
- Title
- Retroviral proteomics and interactomes: intricate balances of cell survival and viral replication
- Creators
- Rachel Van Duyne - George Washington UniversityKylene Kehn-Hall - George Washington UniversityZachary Klase - George Washington UniversityRebecca Easley - George Washington UniversityMohammad Heydarian - George Washington UniversityMohammed Saifuddin - Eastern Virginia Medical SchoolWeilin Wu - George Washington UniversityFatah Kashanchi - George Washington University
- Publication Details
- Expert review of proteomics, v 5(3), pp 507-528
- Publisher
- Informa Healthcare
- Number of pages
- 22
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000256862000011
- Scopus ID
- 2-s2.0-45749104751
- Other Identifier
- 991021902506404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods