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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Returning to Overuse Activity Following a Supraspinatus and Infraspinatus Tear Leads to Joint Damage in a Rat Model
Journal of biomechanics, v 46(11), pp 1818-1824
12 Jun 2013
PMID: 23764174
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Large rotator cuff tears (supraspinatus and infraspinatus) are common in patients that perform overhead activities (laborers, athletes). In addition, following large cuff tears, these patients commonly attempt to return to pre-injury activity levels. However, there is a limited understanding of the damaging effects on the uninjured joint tissues when doing so. Therefore, the objective of this study was to investigate the effect of returning to overuse activity following a supraspinatus and infraspinatus tear on shoulder function and the structural and biological properties of the intact tendons and glenoid cartilage. Forty rats underwent four weeks of overuse followed by detachment of the supraspinatus and infraspinatus tendons and were then randomized into two groups: return to overuse or cage activity. Ambulatory measurements were performed over time and structural and biologic properties of the adjacent tendons and cartilage were evaluated. Results demonstrated that animals returning to overuse activity did not have altered shoulder function but despite this, did have altered cartilage and tendon properties. These mechanical changes corresponded to altered transcriptional regulation of chondrogenic genes within cartilage and tendon. This study helps define the mechanical and biologic mechanisms leading to joint damage and provides a framework for treating active cuff tear patients.
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Details
- Title
- Returning to Overuse Activity Following a Supraspinatus and Infraspinatus Tear Leads to Joint Damage in a Rat Model
- Creators
- Katherine E. Reuther - University of PennsylvaniaStephen J. Thomas - University of PennsylvaniaElisabeth F. Evans - McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PAJennica J. Tucker - University of PennsylvaniaJoseph J. Sarver - University of PennsylvaniaSarah Ilkhani-Pour - University of PennsylvaniaChancellor F. Gray - University of PennsylvaniaPramod Voleti - University of PennsylvaniaDavid L. Glaser - University of PennsylvaniaLouis J. Soslowsky - University of Pennsylvania
- Publication Details
- Journal of biomechanics, v 46(11), pp 1818-1824
- Publisher
- Elsevier
- Grant note
- T32 AR007132 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS P30 AR050950 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS R01 AR056658 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000323091700006
- Scopus ID
- 2-s2.0-84880035131
- Other Identifier
- 991019176799304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biophysics
- Engineering, Biomedical