Journal article
Reversible CD8 expression induced by common cytokine receptor γ chain-dependent cytokines in a cloned CD4+ Th1 cell line
International immunology, v 14(3), pp 259-266
Mar 2002
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
T cells that are intrathymically lineage committed are believed to maintain their CD4 or CD8 co-receptor expression. Here, we investigated whether intrathymic lineage commitment involves irreversible genetic modification or whether co-receptor expression can be reprogrammed depending on external stimuli. The CD4+ Th1 clone 2D6 established from splenic T cells as an IL-12-dependent line survived in culture with IL-2, IL-7 or IL-15 alone. Surprisingly, CD8 expression occurred in 2D6 cells upon replacement of IL-12 with any one of the three cytokines that stimulate the common cytokine receptor γ chain, yielding CD4+CD8+ 2D6 cells. CD8 expression declined when IL-2 was replaced with IL-12 and CD8 induction was inhibited when IL-12 was included in IL-2 or IL-7 culture. Our observations show that even a lineage-committed mature T cell can be reprogrammed for co-receptor expression in response to particular external stimuli.
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Details
- Title
- Reversible CD8 expression induced by common cytokine receptor γ chain-dependent cytokines in a cloned CD4+ Th1 cell line
- Creators
- Cheung-Seog Park - The University of OsakaYi-Fu Yang - The University of OsakaXu-Yu Zhou - The University of OsakaKazuhito Toyooka - The University of OsakaYumi Yashiro-Ohtani - The University of OsakaWoong-Ryeon Park - The University of OsakaMichio Tomura - The University of OsakaXu-Guang Tai - The University of OsakaToshiyuki Hamaoka - The University of OsakaHiromi Fujiwara - The University of Osaka
- Publication Details
- International immunology, v 14(3), pp 259-266
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000174364300003
- Scopus ID
- 2-s2.0-0036200079
- Other Identifier
- 991020099380504721
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- Web of Science research areas
- Immunology