Journal article
Review of ACR hematologic criteria in systemic lupus erythematosus
Lupus, v 13(11), pp 865-868
01 Jan 2004
PMID: 15580984
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Abstract
We have conducted a thorough literature review to evaluate the relative value of the hematologic criterion in making a diagnosis of systemic lupus erythematosus (SLE), its clinical relevance, and its prognostic significance. In the updated 1982 ACR criteria, the presence of one or more of the four elements: 1) hemolytic anemia (with reticulocytosis); 2) leukopenia (<4000/mL on two or more occasions); 3) lymphopenia (<1500/mL on two or more occasions); or 4) thrombocytopenia (<100 000/mL in the absence of offending drugs) is now considered as a single hematologic disorder. The sensitivity and specificity of the individual elements of the hematologic criterion range from 18 to 46% and 89 to 99%, respectively. The accuracy of the hematologic criterion requires proper interpretation. For example, many studies reported the presence of anemia that was not clearly defined and likely included anemia from etiologies other than hemolytic anemia, thereby causing an overestimation of the prevalence. In addition, medications such as corticosteroids and cytotoxic agents, and viral infections, can also contribute to a reduction in lymphocyte count. Despite these limitations, the SLICC committee recommends no change in the elements of the hematologic criterion when this criterion is properly interpreted and other causes of cytopenia are excluded.
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Details
- Title
- Review of ACR hematologic criteria in systemic lupus erythematosus
- Creators
- A H Kao - University of PittsburghS Manzi - University of PittsburghR Ramsey-Goldman - Northwestern University
- Publication Details
- Lupus, v 13(11), pp 865-868
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000225387000007
- Scopus ID
- 2-s2.0-9244230658
- Other Identifier
- 991021934011604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Rheumatology