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Journal article
Review on biofabrication and applications of heterogeneous tumor models
Journal of tissue engineering and regenerative medicine, v 13(11), pp 2101-2120
01 Nov 2019
PMID: 31359625
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Resolving the origin and development of tumor heterogeneity has proven to be a crucial challenge in cancer research. In vitro tumor models have been widely used for both scientific and clinical research. Currently, tumor models based on 2D cell culture, animal models, and 3D cell-laden constructs are widely used. Heterogeneous tumor models, which consist of more than one cell type and mimic cell-cell as well as cell-matrix interactions, are attracting increasing attention. Heterogeneous tumor models can serve as pathological models to study the microenvironment and tumor development such as tumorigenesis, invasiveness, and malignancy. They also provide disease models for drug screening and personalized therapy. In this review, the current techniques, models, and oncological applications regarding 3D heterogeneous tumor models are summarized and discussed.
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Details
- Title
- Review on biofabrication and applications of heterogeneous tumor models
- Creators
- Tiankun Liu - Tsinghua UniversityRui Yao - Tsinghua Univ, Biomfg & Rapid Forming Technol Key Lab Beijing, Beijing, Peoples R ChinaYuan Pang - Tsinghua UniversityWei Sun - Tsinghua Univ, Biomfg & Rapid Forming Technol Key Lab Beijing, Beijing, Peoples R China
- Publication Details
- Journal of tissue engineering and regenerative medicine, v 13(11), pp 2101-2120
- Publisher
- Wiley
- Number of pages
- 20
- Grant note
- 2015ZX09501009 / National Major Special Project on New Drug Discovery 51235006 / Key Projects of the National Natural Science Foundation 2014z21030 / Young Faculty Independent Basic Scientific Research Foundation, Ministry of Education 31500818; 31711530218 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000484003900001
- Scopus ID
- 2-s2.0-85071307995
- Other Identifier
- 991019167518004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Cell & Tissue Engineering
- Cell Biology
- Engineering, Biomedical