Journal article
Review: the role of omega 3 fatty acids in intestinal inflammation
The Journal of nutritional biochemistry, v 12(1), pp 21-32
Jan 2001
PMID: 11179858
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The role of polyunsaturated fatty acids (PUFAs) in inflammatory lesions of the intestines is the subject of increasing research. This review begins with a background discussion of the source, elongation, and desaturation of PUFAs, as well as the role they have played in the human diet through evolution. The available data and hypotheses as to how manipulation of PUFAs might effect the various components of the immune system are then provided. Possible mechanisms by which PUFAs result in immunomodulation include alterations in eicosanoid synthesis, membrane fluidity, signal transduction, intraluminal bacteria, and gene expression. Attention is then turned to the known effects that these polyunsaturated fatty acids have on the various individual components of the immune system including lymphocytes, neutrophils, and antigen presenting cells, as well as the immunoregulatory process of apoptosis. Finally, laboratory data on the role of PUFAs in necrotizing enterocolitis, and to a greater extent inflammatory bowel disease, first as demonstrated in animal models of the disease, and second in human studies are then summarized.
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Details
- Title
- Review: the role of omega 3 fatty acids in intestinal inflammation
- Creators
- Jonathan E Teitelbaum - Monmouth Medical CenterW Allan Walker - Harvard Medical School, Division of Nutrition, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and The Children’s Hospital, Boston, MA, USA
- Publication Details
- The Journal of nutritional biochemistry, v 12(1), pp 21-32
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000167003000004
- Scopus ID
- 2-s2.0-0035147381
- Other Identifier
- 991019168711904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Nutrition & Dietetics