Revisiting 2-Substituted-4(1 H )-Quinolones for Targeting the Plasmodium falciparum Cytochrome bc 1 Complex

The authors would like to acknowledge the contributions of the OHSU Bioanalytical Shared Resource/Pharmacokinetics Core (Research Resource ID: SCR_009963) and the Medicinal Chemistry Core (Research Resource ID: SCR_019048). The Murdock Charitable Trust is acknowledged for providing instrument funding for the BSR/PK Core Facility (BSR/PK Core Research Resource Identifier RRID:SCR_009963). Research carried out by WRAIR was supported in part by an appointment to the Department of Defense (DoD) Research Participation Program administered by Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between U.S. Department of Energy (DOE) and the DOD. ORISE is managed by ORAU under DOE contact number DE-SC0014664. The authors thank WRAIR Entomology for the production and provision of Plasmodium berghei-infected mosquitoes and sporozoites. The authors also acknowledge the Armed Forces Research Institute of Medical Sciences (AFRIMS), Thailand, for the generation and provision of Plasmodium cynomolgi-infected Anopheles dirus mosquitoes used in these studies.