Journal article
Rhythmic Bursting in the Pre-Bötzinger Complex: Mechanisms and Models
Progress in brain research, v 209, pp 1-23
2014
PMID: 24746040
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The pre-Bötzinger complex (pre-BötC), a neural structure involved in respiratory rhythm generation, can generate rhythmic bursting activity
in vitro
that persists after blockade of synaptic inhibition. Experimental studies have identified two mechanisms potentially involved in this activity: one based on the persistent sodium current (
I
NaP
) and the other involving calcium (
I
Ca
) and/or calcium-activated nonspecific cation (
I
CAN
) currents. In this modeling study, we investigated bursting generated in single neurons and excitatory neural populations with randomly distributed conductances of
I
NaP
and
I
Ca
. We analyzed the possible roles of these currents, the Na
+
/K
+
pump, synaptic mechanisms, and network interactions in rhythmic bursting generated under different conditions. We show that a population of synaptically coupled excitatory neurons with randomly distributed
I
NaP
- and/or
I
CAN
-mediated burst generating mechanisms can operate in different oscillatory regimes with bursting dependent on either current or independent of both. The existence of multiple oscillatory regimes and their state dependence may explain rhythmic activities observed in the pre-BötC under different conditions.
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Details
- Title
- Rhythmic Bursting in the Pre-Bötzinger Complex: Mechanisms and Models
- Creators
- Ilya A Rybak - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USAYaroslav I Molkov - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USAPatrick E Jasinski - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USANatalia A Shevtsova - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USAJeffrey C Smith - Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
- Publication Details
- Progress in brain research, v 209, pp 1-23
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000349323900002
- Scopus ID
- 2-s2.0-84923207457
- Other Identifier
- 991014877776504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Physiology