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Ribotype Stability of Serial Pulmonary Isolates of Pseudomonas cepacia
Journal article   Peer reviewed

Ribotype Stability of Serial Pulmonary Isolates of Pseudomonas cepacia

John J. LiPuma, Margaret C. Fisher, Sue E. Dasen, Joel E. Mortensen and Terrence L. Stull
The Journal of infectious diseases, v 164(1)
Jul 1991
DOI: https://doi.org/10.1093/infdis/164.1.133
PMID: 1711551
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Eighty-three isolates of Pseudomonas cepacia were recovered from respiratory secretions from 12 chronically colonized cystic fibrosis patients and examined by ribotype analysis. In 9 patients, the ribotype of the cultured P. cepacia remained unchanged throughout the entire period of observation, indicating chronic pulmonary colonization with a single strain. In each of the remaining 3 patients, two genetically distinct strains were detected among serial P. cepacia isolates. No significant change in clinical condition was correlated with the change in identity of the colonizing strain. In control experiments, the stability of strain ribotype was demonstrated among isolates that had been subcultured 100 times in vitro and among isolates recovered from chronically colonized mice. These data demonstrate the utility of ribotype analysis and indicate that most chronically colonized cystic fibrosis patients harbor a single strain of P. cepacia for prolonged periods.

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39 citations in Web of Science
3 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Immunology
Infectious Diseases
Microbiology
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