Journal article
Risk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status
American journal of epidemiology, v 161(10), pp 916-925
15 May 2005
PMID: 15870155
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Research suggests that heredity and early fetal development play a causal role in autism. This case-control study explored the association between perinatal factors, parental psychiatric history, socioeconomic status, and risk of autism. The study was nested within a cohort of all children born in Denmark after 1972 and at risk of being diagnosed with autism until December 1999. Prospectively recorded data were obtained from nationwide registries in Denmark. Cases totaled 698 children with a diagnosis of autism; each case was individually matched by gender, birth year, and age to 25 controls. Analyses by conditional logistic regression produced risk ratios and 95% confidence intervals. Adjusted analyses showed that the risk of autism was associated with breech presentation (risk ratio (RR) = 1.63, 95% confidence interval (CI): 1.18, 2.26), low Apgar score at 5 minutes (RR = 1.89, 95% CI: 1.10, 3.27), gestational age at birth <35 weeks (RR = 2.45, 95% CI: 1.55, 3.86), and parental psychiatric history (schizophrenia-like psychosis: RR = 3.44, 95% CI: 1.48, 7.95; affective disorder: RR = 2.91, 95% CI: 1.65, 5.14). Analyses showed no statistically significant association between risk of autism and weight for gestational age, parity, number of antenatal visits, parental age, or socioeconomic status. Results suggest that prenatal environmental factors and parental psychopathology are associated with the risk of autism. These factors seem to act independently.
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Details
- Title
- Risk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status
- Creators
- Heidi Jeanet Larsson - Montreal Neurological Institute and HospitalWilliam W. Eaton - Johns Hopkins UniversityKreesten Meldgaard Madsen - Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, DenmarkMogens Vestergaard - Danish National Institute of Public HealthAnne Vingaard Olesen - Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, DenmarkEsben Agerbo - National Centre for Register-based Research, University of Aarhus, Aarhus, DenmarkDiana Schendel - Danish National Institute of Public HealthPoul Thorsen - Montreal Neurological Institute and HospitalPreben Bo Mortensen - National Centre for Register-based Research, University of Aarhus, Aarhus, Denmark
- Publication Details
- American journal of epidemiology, v 161(10), pp 916-925
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000228930000002
- Scopus ID
- 2-s2.0-18544369453
- Other Identifier
- 991021463539304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health