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Risk factors associated with clindamycin-resistant, methicillin-resistant Staphylococcus aureus in hand abscesses
Journal article   Peer reviewed

Risk factors associated with clindamycin-resistant, methicillin-resistant Staphylococcus aureus in hand abscesses

Rick Tosti, Arianna Trionfo, John Gaughan and Asif M Ilyas
The Journal of hand surgery (American ed.), v 40(4), pp 673-676
01 Apr 2015
DOI: https://doi.org/10.1016/j.jhsa.2014.12.044
PMID: 25707549
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Abscess - microbiology Age Factors Anti-Bacterial Agents Clindamycin - therapeutic use Cross Infection - drug therapy Cross Infection - epidemiology Drug Resistance, Multiple, Bacterial Hand - microbiology Humans Methicillin-Resistant Staphylococcus aureus Multivariate Analysis Risk Factors Staphylococcal Infections - drug therapy Staphylococcal Infections - epidemiology Substance Abuse, Intravenous - epidemiology
To identify risk factors for clindamycin resistance in acute hand abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA). We performed a retrospective review of 247 consecutive culture-positive hand abscesses from 2010 to 2012 at an urban hospital. Historical and laboratory data from patients with abscesses that grew MRSA with and without clindamycin resistance were compared in a multivariate analysis. Methicillin-resistant Staphylococcus aureus grew on culture from 103 abscesses; 16% of those isolates were resistant to clindamycin. Multivariate analysis showed that younger age, intravenous drug use, and nosocomial acquired MRSA were significant risk factors for concurrent clindamycin resistance. Patients with a history of intravenous drug use and nosocomial acquired MRSA were, respectively, 11 and 5 times more likely to have concurrent clindamycin resistance. History of MRSA infection and human immunodeficiency virus were not identified as risk factors. Patients with a history of intravenous drug use or recent contact with health care facilities appear to be a potential reservoir for emerging multidrug-resistant MRSA. Selection of clindamycin as an empiric antibiotic should be especially avoided for these groups. Prognostic III.

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8 citations in Web of Science
15 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Orthopedics
Surgery
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