Journal article
Risk factors for nontuberculous mycobacterial infections in solid organ transplant recipients: a case-control study
Transplant infectious disease, v 16(1), pp 76-83
01 Feb 2014
PMID: 24350627
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundThe epidemiology of nontuberculous mycobacteria (NTM) disease in solid organ transplant recipients is poorly defined.
MethodsWe identified all solid organ transplant recipients with NTM disease at a single center over a 7.5-year period, and collected data on patient demographics, co-morbidities, immunosuppressive medications, and rejection. We conducted a case-control study to identify risk factors for disease, matching 3 control patients to each case patient by date of transplantation.
ResultsA total of 34 cases of NTM disease occurred during the study period, involving 6 single lung, 13 bilateral lung, 8 heart, 4 liver, 2 kidney, and 1 pancreas-kidney recipients. Cases were predominantly male (24/34), with a median age of 55years (interquartile range [IQR]: 46-61years), and developed after a median of 8months post transplantation (IQR: 2-87months). Mycobacterium abscessus and Mycobacterium avium complex were the most common pathogens, and the lung (including pleura) was the most common site of disease. In the adjusted case-control analysis, lung transplant recipients had the highest risk of NTM disease.
ConclusionsAdditional studies are needed to evaluate the role of targeted surveillance measures for NTM disease in high-risk patients, particularly lung transplant recipients, and to characterize the mechanisms of disease acquisition.
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Details
- Title
- Risk factors for nontuberculous mycobacterial infections in solid organ transplant recipients: a case-control study
- Creators
- S. A. Longworth - University of PennsylvaniaC. Vinnard - Drexel UniversityI. Lee - Merck & Co., Inc., Rahway, NJ, USA (United States)K. D. Sims - Bristol‐Myers Squibb , Princeton, New Jersey, USAT. D. Barton - University of PennsylvaniaE. A. Blumberg - University of Pennsylvania
- Publication Details
- Transplant infectious disease, v 16(1), pp 76-83
- Publisher
- Wiley
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000331182400009
- Scopus ID
- 2-s2.0-84893842274
- Other Identifier
- 991019168839904721
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InCites Highlights
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Transplantation