Journal article
Risk of Autism Spectrum Disorders in children born after assisted conception. A population based follow-up study
Journal of epidemiology and community health (1979), v 65(6), pp 497-502
01 Jun 2011
PMID: 20584728
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract Objectives: to assess the risk of Autism Spectrum Disorders (ASD) in children born after assisted conception compared to children born after natural conception (NC). Design: population based follow-up study. Setting: all children born alive in Denmark 1995-2003. Participants: 588,967 children born in Denmark from January 1995 to December 2003. Assisted conception was defined as in vitro fertilization (IVF), with or without intracytoplasmic sperm injection (ICSI) and ovulation induction (OI) with or without subsequent insemination. Children exposed to IVF or OI were identified in the IVF Register and in the Danish Drug Prescription Register. Main outcome measures: a diagnosis of Autism Spectrum Disorders in the Danish Psychiatric Central Register. Results: 33,139 (5.6%) of all children born in Denmark 1995-2003 resulted from assisted conception and 225 (0.68%) of these exposed children received an ASD diagnosis. Of the 555,828 NC children born in this period 3,394 (0.61%) received an ASD diagnosis. The follow-up time was 4 to 13 years with a median follow-up time of 9 years. In crude analyses children born after assisted conception had an increased risk of getting an ASD diagnosis, crude hazard rate ratio (HRR) 1.25 (95% CI 1.09-1.43). In analyses adjusting for maternal age, educational level, parity, smoking, birth weight and multiplicity the risk disappeared, adjusted HRR 1.13. (95% CI 0.97-1.31). However, subgroup analyses that suggest possible associations in women who received FSH medications indicate the need for further study. Discussion: this population based follow-up study demonstrated no risk of ASD in children born after assisted conception.
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Details
- Title
- Risk of Autism Spectrum Disorders in children born after assisted conception. A population based follow-up study
- Creators
- Dorte Hvidtjørn - Aarhus UniversityJakob Grove - Aarhus UniversityDiana Schendel - Centers for Disease Control and PreventionLaura Schieve - Centers for Disease Control and PreventionClaus Sv??rke - Aarhus UniversityErik Ernst - Skejby University HospitalPoul Thorsen - Emory University
- Publication Details
- Journal of epidemiology and community health (1979), v 65(6), pp 497-502
- Publisher
- BMJ Publishing Group
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000290209400006
- Scopus ID
- 2-s2.0-79956200221
- Other Identifier
- 991021463555404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health