Journal article
Risk of Complications After Endoscopic Retrograde Cholangiopancreatography in Pregnancy: A Propensity-Matched Analysis
Digestive diseases and sciences, v 68(11), pp 4266-4273
01 Nov 2023
PMID: 37741950
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundStudies have suggested higher complication rates after endoscopic retrograde cholangiopancreatography (ERCP) in pregnancy.AimsWe performed a propensity-matched cohort analysis to assess the risk of ERCP-related complications among pregnant women in the United States.MethodsThe TriNetX database was analyzed to identify pregnant and non-pregnant females between 18 and 50 years of age who underwent ERCP. One-to-one propensity score matching was performed for age and race. Outcomes included risk of post-ERCP pancreatitis (PEP), gastrointestinal (GI) bleeding, perforation within 7 days, and infections within 30 days of ERCP. Subgroup analysis was performed to assess the risk of PEP based on indication for ERCP.ResultsThe risk of PEP was higher in the pregnant cohort compared to controls, 10.3% vs 6.08%, adjusted odds ratio (aOR) 1.77, 95% confidence interval (CI) 1.20-2.61; p = 0.003. We found no difference in the risk of GI bleeding, perforation, and infections between the two cohorts. There was no difference in the risk of PEP in the pregnant cohort compared to controls who underwent ERCP for acute choledocholithiasis (4.2% vs 2.1%, aOR 1.98, 95% CI 0.97-4.03, p = 0.5) or ascending cholangitis (18.6% vs 14.7%, aOR 1.32, 95% CI 0.52-3.39, p = 0.55). There was no difference in the risk of PEP in the pregnant cohort after sensitivity analysis based on age, race, obesity, and indomethacin use.ConclusionPregnant females are at an increased risk of PEP but not GI bleeding, perforation, and infections when compared to non-pregnant controls. Clinicians should be cautious when proceeding with ERCP during pregnancy.
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Details
- Title
- Risk of Complications After Endoscopic Retrograde Cholangiopancreatography in Pregnancy: A Propensity-Matched Analysis
- Creators
- Dushyant Singh Dahiya - MotilitySaurabh Chandan - Creighton UniversityAakash Desai - Case Western Reserve UniversityDaryl Ramai - University of UtahBabu P. Mohan - University of UtahAntonio Facciorusso - University of FoggiaMohammad Bilal - Minneapolis VA Health Care SystemNeil R. Sharma - Parkview HealthDouglas G. Adler - Porter Adventist HospitalGursimran S. Kochhar - Allegheny Health Network
- Publication Details
- Digestive diseases and sciences, v 68(11), pp 4266-4273
- Publisher
- Springer Nature
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001142526700015
- Scopus ID
- 2-s2.0-85171982084
- Other Identifier
- 991022135629704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology