Journal article
Role for Plastin in Host Defense Distinguishes Integrin Signaling from Cell Adhesion and Spreading
Immunity (Cambridge, Mass.), v 19(1)
01 Jul 2003
PMID: 12871642
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Integrin ligation activates both cell adhesion and signal transduction, in part through reorganization of the actin cytoskeleton. Plastins (also known as fimbrins) are actin-crosslinking proteins of the cortical cytoskeleton present in all cells and conserved from yeast to mammals. Here we show that plastin-deficient polymorphonuclear neutrophils (PMN) are deficient in killing the bacterial pathogen
Staphylococcus aureus in vivo and in vitro, despite normal phagocytosis. Like integrin β2-deficient PMN, plastin-deficient PMN cannot generate an adhesion-dependent respiratory burst, because of markedly diminished integrin-dependent syk activation. Unlike β2
–/– PMN, plastin-deficient PMN adhere and spread normally. Deficiency of plastin thus separates the classical integrin receptor functions of adhesion and spreading from intracellular signal transduction.
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Details
- Title
- Role for Plastin in Host Defense Distinguishes Integrin Signaling from Cell Adhesion and Spreading
- Creators
- Hua Chen - University of California, San FranciscoAttila Mocsai - University of California, San FranciscoHong Zhang - University of California, San FranciscoRong-Xian Ding - University of California, San FranciscoJ.Hiroshi Morisaki - University of California, San FranciscoMichael White - Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 USAJacob M. Rothfork - Research Service, Albuquerque VAMC, Albuquerque, NM 87108 USAPatrick Heiser - University of California, San FranciscoEmma Colucci-Guyon - Institut PasteurClifford A. Lowell - University of California, San FranciscoHattie D. Gresham - Research Service, Albuquerque VAMC, Albuquerque, NM 87108 USAPaul M. Allen - Washington University in St. LouisEric J. Brown - University of California, San Francisco
- Publication Details
- Immunity (Cambridge, Mass.), v 19(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000184260400011
- Scopus ID
- 2-s2.0-0038106595
- Other Identifier
- 991020837831004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology