Journal article
Role of Cholesterol on Binding of Amyloid Fibrils to Lipid Bilayers
The journal of physical chemistry. B, v 124(15), pp 3036-3042
16 Apr 2020
PMID: 32207622
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Molecular dynamics simulations are used to provide insights into the molecular mechanisms accounting for binding of amyloid fibrils to lipid bilayers and to study the effect of cholesterol in this process. We show that electrostatic interactions play an important role in fibril–bilayer binding and cholesterol modulates this interaction. In particular, the interaction between positive residues and lipid head groups becomes more favorable in the presence of cholesterol. Consistent with experiments, we find that cholesterol enhances fibril–membrane binding.
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Details
- Title
- Role of Cholesterol on Binding of Amyloid Fibrils to Lipid Bilayers
- Creators
- Cristiano L Dias - Department of PhysicsSharareh Jalali - Department of PhysicsYanxing Yang - Department of PhysicsLuis Cruz - Drexel University
- Publication Details
- The journal of physical chemistry. B, v 124(15), pp 3036-3042
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000526368900007
- Scopus ID
- 2-s2.0-85083544996
- Other Identifier
- 991019296793904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Physical