Journal article
Role of F-18-NaF-PET in assessing aortic valve calcification with age
American journal of nuclear medicine and molecular imaging, v 10(1), pp 47-56
01 Jan 2020
PMID: 32211218
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aortic valve calcification is a slow and progressive pathological process that can manifest in various degrees from mild thickening of the valve known as aortic sclerosis to severe calcification that hinders the leaflet motion, known as aortic stenosis. The evolving concept of aortic calcification is thought to result from infiltration of macrophages and T-lymphocytes. Moreover, the incidence of aortic valve calcification increases with age, in particular over the age of 50. In this study, we aimed to assess F-18-sodium fluoride (F-18-NaF) uptake by the aortic valve on PET/CT scans performed in two age groups; 25-35 and 50-75 years of age. We hypothesized that patients aged 50-75, comprising of both healthy and high risk for cardiovascular disease (CVD), would have higher uptake of F-18-NaF than patients aged 25-35 and further that in the former group those who were at high risk for CVD had also higher F-18-NaF uptake. The 25-35-year group comprised of 6 males and 6 females, mean age 30 +/- 3.5 years, while the 50-75-year group included 18 males and 20 females, mean age 61 +/- 6.2 years. All underwent PET/CT imaging 90 minutes following the injection of 2.2 MBq of F-18-NaF per kg body weight. Aortic valve analysis was performed on axial sections using standard guided computer software (OsiriX MD software, version 9.0.02). The average aortic valve SUVmean was calculated for each patient. Univariate regression models stratified by age group were employed to determine the association of SUVmean with age. In the 50-75-year group, explanatory multivariable regression modeling was applied using available demographic and baseline information. SUVmean was found to be higher in the 50-75 age group than in the 25-35 age group: 0.91 +/- 0.25 and 0.86 +/- 0.26, respectively. The association of SUVmean with age was much stronger in individuals aged 50-75 years (r = 0.64, P<0.001) than individuals aged 25-35 years (r = 0.20, P = 0.53). In addition, in the 50-75 age group the association was much stronger in subjects with a high risk of CVD than in individuals without: r = 0.68, P = 0.001 versus r = 0.48, P = 0.042. Furthermore, the SUVmean was found to be higher in the high-risk group aged 50-75 than in the low-risk healthy group aged 50-75: 0.98 +/- 0.32 and 0.83 +/- 0.13. Aortic valve F-18-NaF uptake was higher in patients belonging to the age group of 50-75 years and correlated positively with age and high risk of CVD. These data provide evidence for a potential role of 18F-NaF PET/CT in identifying calcific changes in the aortic valve and may help direct therapeutic intervention prior to the development of symptomatic valvular disease.
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Details
- Title
- Role of F-18-NaF-PET in assessing aortic valve calcification with age
- Creators
- Chaitanya Rojulpote - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USAAustin J. Borja - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USAVincent Zhang - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USAMahmoud Aly - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USABenjamin Koa - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USASiavash M. Seraj - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USAWilliam Y. Raynor - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USAEsha Kothekar - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USAFatemeh Kaghazchi - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USAThomas J. Werner - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USAOke Gerke - College Station Medical CenterPoul Flemming Hoilund-Carlsen - College Station Medical CenterAbass Alavi - Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA
- Publication Details
- American journal of nuclear medicine and molecular imaging, v 10(1), pp 47-56
- Publisher
- E-Century Publishing Corp
- Number of pages
- 10
- Grant note
- Jorgen and Gisela Thrane's Philanthropic Research Foundation, Broager, Denmark
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000519622200003
- Other Identifier
- 991019350580804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging