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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Role of Intestinal Dysbiosis and Nutrition in Rheumatoid Arthritis
Cells (Basel, Switzerland), v 11(15), 2436
05 Aug 2022
PMID: 35954278
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rheumatoid arthritis is a chronic systemic immune-mediated disease caused by genetic and environmental factors. It is often characterized by the generation of autoantibodies that lead to synovial inflammation and eventual multi-joint destruction. A growing number of studies have shown significant differences in the gut microbiota composition of rheumatoid arthritis (RA) patients compared to healthy controls. Environmental factors, and changes in diet and nutrition are thought to play a role in developing this dysbiosis. This review aims to summarize the current knowledge of intestinal dysbiosis, the role of nutritional factors, and its implications in the pathogenesis of rheumatoid arthritis and autoimmunity. The future direction focuses on developing microbiome manipulation therapeutics for RA disease management.
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Details
- Title
- Role of Intestinal Dysbiosis and Nutrition in Rheumatoid Arthritis
- Creators
- Malavikalakshmi Attur - Drexel University, College of MedicineJose U Scher - New York UniversitySteven B. Abramson - New York UniversityMukundan Attur - New York University
- Publication Details
- Cells (Basel, Switzerland), v 11(15), 2436
- Publisher
- MDPI
- Grant note
- R01AR074500; 1UC2AR081034-01 / National Institute of Health; National Institute of Arthritis and Musculoskeletal and Skin Disease The Beatrice Snyder Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000840148800001
- Scopus ID
- 2-s2.0-85136342525
- Other Identifier
- 991022005885504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology