Journal article
Role of Nuclear Factor Kappa B (NF-kappa B) in Growth Plate Chondrogenesis
PEDIATRIC ENDOCRINOLOGY REVIEWS PER, v 13(4), pp 720-730
01 Jun 2016
PMID: 27464415
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nuclear Factor kappa B (NF-kappa B) is a group of seven transcription factors. Upon activation by a variety of stimuli, NF-kappa B translocates to the nucleus and modulates the expression of target genes involved in cell growth, survival, and death.
Previous evidence indicates that NF-kappa B regulates bone growth and development. We have shown that the NF-kappa B p65 is expressed in the growth plate and facilitates longitudinal bone growth by inducing chondrocyte proliferation and differentiation and by preventing apoptosis. Furthermore, we have demonstrated in rodents that NF-kappa B expressed in growth plate chondrocytes mediates the promoting effects of GH and IGF-1 on longitudinal bone growth and growth plate chondrogenesis. Lastly, functional studies carried out in two children with growth failure and GH insensitivity, and affected by two different mutations impairing NF-kappa B activation, indicate that NF-kappa B also mediates the growth-promoting effects of GH in humans.
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Details
- Title
- Role of Nuclear Factor Kappa B (NF-kappa B) in Growth Plate Chondrogenesis
- Creators
- Francesco De Luca - Drexel Univ, Sch Med, Sect Endocrinol & Diabet, St Christophers Hosp Children, Philadelphia, PA 19104 USA
- Publication Details
- PEDIATRIC ENDOCRINOLOGY REVIEWS PER, v 13(4), pp 720-730
- Publisher
- Medical Media
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000378464100004
- Scopus ID
- 2-s2.0-85003053046
- Other Identifier
- 991019169600704721
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- Web of Science research areas
- Endocrinology & Metabolism