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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Role of O-GlcNAcylation on cancer stem cells: Connecting nutrient sensing to cell plasticity
Advances in cancer research, v 157, pp 195-228
2023
PMID: 36725109
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tumor growth and metastasis can be promoted by a small sub-population of cancer cells, termed cancer stem-like cells (CSCs). While CSCs possess capability in self-renewing and differentiating, the hierarchy of CSCs during tumor growth is highly plastic. This plasticity in CSCs fate and function can be regulated by signals from the tumor microenvironment. One emerging pathway in CSCs that connects the alteration in microenvironment and signaling network in cancer cells is the hexosamine biosynthetic pathway (HBP). The final product of HBP, UDP-N-acetylglucosamine (UDP-GlcNAc), is utilized for glycosylating of membrane and secreted proteins, but also nuclear and cytoplasmic proteins by the post-translational modification O-GlcNAcylation. O-GlcNAcylation and its enzyme, O-GlcNAc transferase (OGT), are upregulated in nearly all cancers and been linked to regulate many cancer cell phenotypes. Recent studies have begun to connect OGT and O-GlcNAcylation to regulation of CSCs. In this review, we will discuss the emerging role of OGT and O-GlcNAcylation in regulating fate and plasticity of CSCs, as well as the potential in targeting OGT/O-GlcNAcylation in CSCs.
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Details
- Title
- Role of O-GlcNAcylation on cancer stem cells: Connecting nutrient sensing to cell plasticity
- Creators
- Giang Le Minh - Drexel UniversityMauricio J Reginato
- Publication Details
- Advances in cancer research, v 157, pp 195-228
- Publisher
- Elsevier
- Grant note
- U01 CA244303 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:001075073400008
- Scopus ID
- 2-s2.0-85135068306
- Other Identifier
- 991020099923004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Oncology