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Journal article
Role of Peripheral Immune Cells for Development and Recovery of Chronic Pain
Frontiers in immunology, v 12, pp 641588-641588
22 Feb 2021
PMID: 33692810
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic neuropathic pain (CNP) is caused by a lesion or disease of the somatosensory nervous system. It affects similar to 8% of the general population and negatively impacts a person's level of functioning and quality of life. Its resistance to available pain therapies makes CNP a major unmet medical need. Immune cells have been shown to play a role for development, maintenance and recovery of CNP and therefore are attractive targets for novel pain therapies. In particular, in neuropathic mice and humans, microglia are activated in the dorsal horn and peripheral immune cells infiltrate the nervous system to promote chronic neuroinflammation and contribute to the initiation and progression of CNP. Importantly, immunity not only controls pain development and maintenance, but is also essential for pain resolution. In particular, regulatory T cells, a subpopulation of T lymphocytes with immune regulatory function, and macrophages were shown to be important contributors to pain recovery. In this review we summarize the interactions of the peripheral immune system with the nervous system and outline their contribution to the development and recovery of pain.
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Details
- Title
- Role of Peripheral Immune Cells for Development and Recovery of Chronic Pain
- Creators
- John R. Bethea - Drexel UniversityRoman Fischer - University of Stuttgart
- Publication Details
- Frontiers in immunology, v 12, pp 641588-641588
- Publisher
- Frontiers Media Sa
- Number of pages
- 7
- Grant note
- MJFF18334 / Michael J. Fox Foundation R01NS051709; R01NS111761; R01NS106908; R01NS096971 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000626014200001
- Scopus ID
- 2-s2.0-85102335051
- Other Identifier
- 991019168691204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology