Journal article
Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly
Experimental gerontology, v 37(2), pp 427-439
2002
PMID: 11772530
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
While influenza immunization significantly reduces the risk of pneumonia and associated deaths, vaccination of elderly only affords 30–50% protection against influenza disease. The purpose of this study was to: (1) evaluate the consistency of immune responses across multiple years in young and elderly; (2) determine the contribution of antibody and cell-mediated responses in protection after immunization with influenza vaccine. Independently living healthy elderly (>200/year; mean age 78.8–80.6/year) were recruited yearly in this four year study. The results clearly demonstrate: (1) both young and elderly consistently produced significant antibody and T cell proliferative responses to influenza vaccine upon yearly immunization; however, both responses of elderly were significantly and consistently lower than young. (2) Percentages of both young and elderly demonstrating protective titers (i.e. HI≥40) increased post-immunization each year, but were consistently higher in young compared to elderly. (3) The risk of developing influenza disease after immunization was highest among elderly demonstrating neither antibody nor cell-mediated responses. Importantly, the risk of influenza disease was comparable in elderly demonstrating a cell-mediated response alone, an antibody response alone, or both cell-mediated and antibody responses. This suggests that cell-mediated responses play a significant role in protection in at least a subset of elderly from influenza disease after immunization.
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Details
- Title
- Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly
- Creators
- Donna M Murasko - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine and Public Health, 2900 Queen Lane, Philadelphia, PA 19129, USAErica D Bernstein - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine and Public Health, 2900 Queen Lane, Philadelphia, PA 19129, USAElizabeth M Gardner - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine and Public Health, 2900 Queen Lane, Philadelphia, PA 19129, USAPeter Gross - Department of Internal Medicine, Hackensack University Medical Center, Hackensack, NJ 07601, USAGary Munk - Department of Internal Medicine, Hackensack University Medical Center, Hackensack, NJ 07601, USASandra Dran - Department of Internal Medicine, Hackensack University Medical Center, Hackensack, NJ 07601, USAElias Abrutyn - Department of Medicine, MCP Hahnemann University Schools of Medicine and Public Health, 2900 Queen Lane, Philadelphia, PA 19129, USA
- Publication Details
- Experimental gerontology, v 37(2), pp 427-439
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000173389000029
- Scopus ID
- 2-s2.0-0037012001
- Other Identifier
- 991014878515604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology