Journal article
Role of medical management of cardiogenic shock in the era of mechanical circulatory support
Current opinion in cardiology, v 37(3), pp 250-260
01 May 2022
PMID: 35612937
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose of review The goal of this review is to summarize the current knowledge on the role of medical management of cardiogenic shock in the era of mechanical circulatory support based on important lessons from clinical trials and routine clinical practice, with a focus on providing practical recommendations that can improve contemporary in-hospital management. Recent findings Despite an increasing number of invasive therapies being used to manage cardiogenic shock, evidence-based treatment regimens known to improve outcomes are limited. Medical management of cardiogenic shock includes pharmacological interventions aimed at optimizing determinants of cardiac output-contractility, preload, afterload, and heart rate. In this regard, inotropes and vasopressors remain cornerstone therapies for the management of cardiogenic shock. Norepinephrine has shown potential vasopressor advantage with compared with dopamine, and although milrinone and dobutamine are both considered appropriate first-line inotropes, there is limited data to guide selection, and a recent randomized clinical trial found no significant differences in the treatment of cardiogenic shock. In the absence of an evidence-based management approach to cardiogenic shock, clinical guidelines are based on expert opinion and routine clinical practice patterns. Further studies focusing on clinical outcomes among specific cardiogenic shock phenotypes are needed to better assess the clinical efficacy of these agents.
Metrics
Details
- Title
- Role of medical management of cardiogenic shock in the era of mechanical circulatory support
- Creators
- Vanessa Blumer - Duke UniversityJeffrey Marbach - Beth Israel Deaooness Medioal Ctr, Boston, MA USATara Veasey - Allegheny Health NetworkManreet Kanwar - Allegheny Health Network
- Publication Details
- Current opinion in cardiology, v 37(3), pp 250-260
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiology
- Web of Science ID
- WOS:000799949500009
- Scopus ID
- 2-s2.0-85131107202
- Other Identifier
- 991021932104704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems