Journal article
Role of resident CNS cell populations in HTLV-1-associated neuroinflammatory disease
Frontiers in bioscience, v 14(3), pp 1152-1168
01 Jan 2009
PMID: 19273122
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human T cell leukemia virus type 1 (HTLV-1), the first human retrovirus discovered, is the etiologic agent for a number of disorders; the two most common pathologies include adult T cell leukemia (ATL) and a progressive demyelinating neuroinflammatory disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The neurologic dysfunction associated with HAM/TSP is a result of viral intrusion into the central nervous system (CNS) and the generation of a hyperstimulated host response within the peripheral and central nervous system that includes expanded populations of CD4+ and CD8+ T cells and proinflammatory cytokines/chemokines in the cerebrospinal fluid (CSF). This robust, yet detrimental immune response likely contributes to the death of myelin producing oligodendrocytes and degeneration of neuronal axons. The mechanisms of neurological degeneration in HAM/TSP have yet to be fully delineated in vivo and may involve the immunogenic properties of the HTLV-1 transactivator protein Tax. This comprehensive review characterizes the available knowledge to date concerning the effects of HTLV-1 on CNS resident cell populations with emphasis on both viral and host factors contributing to the genesis of HAM/TSP.
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Details
- Title
- Role of resident CNS cell populations in HTLV-1-associated neuroinflammatory disease
- Creators
- Veronique Lepoutre - Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USAPooja JainKevin QuannBrian WigdahlZafar K Khan
- Publication Details
- Frontiers in bioscience, v 14(3), pp 1152-1168
- Publisher
- United States
- Grant note
- R01 CA054559 / NCI NIH HHS CA054559 / NCI NIH HHS R01 AI077414 / NIAID NIH HHS R01 CA054559-15 / NCI NIH HHS R01 CA054559-13A1 / NCI NIH HHS R01 AI077414-01A2 / NIAID NIH HHS R01 CA054559-14 / NCI NIH HHS 2R1 CA054559 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000262352400073
- Scopus ID
- 2-s2.0-63849344060
- Other Identifier
- 991014877990104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology