Journal article
Role of subcellular shear-stress distributions in endothelial cell mechanotransduction
Annals of biomedical engineering, v 30(4), pp 472-482
Apr 2002
PMID: 12085999
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The endothelium of blood vessels presents a wavy surface to the flowing blood. The subcellular distribution of shear stress depends on the shape and orientation of the cells and on their spatial arrangement within the monolayer. By studying details of the distribution of stress at this scale and the morphological responses that serve to modify the distribution, we can gain insight into the physical mechanisms by which the cell senses its fluid mechanical environment. The rapidly growing body of evidence indicates that endothelial cells discriminate between subtle variations in the exact loading conditions including differences in temporal and spatial gradients of shear stress, steady and pulsatile laminar flow, and laminar and turbulent flows. While in a few studies the effects of these individual flow characteristics have been carefully isolated, it is difficult to assess the relative importance of any one parameter. To interpret the relationships between isolated flow characteristics or the integrated effects of combined loading conditions and the biochemical signaling events that mediate the cell response, a full stress analysis of the cell is needed. The microscopic distribution of shear stress acting upon the cell surface provides the boundary condition for such an analysis. Experimental and analytical tools are being developed to assess the stress distribution throughout the cellular structures that might be involved in mechanotransduction.
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Details
- Title
- Role of subcellular shear-stress distributions in endothelial cell mechanotransduction
- Creators
- Kenneth A Barbee - School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104, USA. barbee@coe.drexel.edu
- Publication Details
- Annals of biomedical engineering, v 30(4), pp 472-482
- Publisher
- United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000176315300006
- Scopus ID
- 2-s2.0-0035989445
- Other Identifier
- 991014878333704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical