Journal article
Role of the Na +-Ca 2+ and Na +-H + antiporters in prolactin release from anterior pituitary cells in primary culture
European journal of pharmacology, v 294(1), pp 11-15
1995
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
2′,4′-dimethylbenzamilamiloride (DMB), a somewhat selective inhibitor of the Na
+-Ca
2+ exchanger, in concentrations of 10, 30 and 100 μM did not produce any significant effect on baseline prolactin release from anterior pituitary cells in primary culture. When prolactin secretion was stimulated by the inhibitor of the Na
+-K
+-ATPase, ouabain, that activates the Na
+-Ca
2+ exchanger as a Ca
2+-influx pathway, DMB was able to produce inhibition of prolactin secretion. 5-(
N,N-hexamethylene) amiloride (HMA), another amiloride analog which specifically inhibits the Na
+-H
+ antiporter and has no inhibitory activity on the Na
+-Ca
2+ exchanger, at the concentrations of 0.1, 1 and 10 μM, did not affect basal prolactin release whereas it significantly reduced prolactin release stimulated by thyrotropin releasing hormone (TRH) (1 μM). These results suggest that the Na
+-Ca
2+ antiporter is involved in the process of prolactin release elicited by the inhibition of the Na
+-K
+-ATPase whereas the Na
+-H
+ antiporter is involved in the prolactin secretion elicited by TRH.
Metrics
Details
- Title
- Role of the Na +-Ca 2+ and Na +-H + antiporters in prolactin release from anterior pituitary cells in primary culture
- Creators
- Gianfranco Di Renzo - University of Naples Federico IISalvatore Amoroso - University of Naples Federico IIAntonella Bassi - University of Naples Federico IIAlessandro Fatatis - University of Naples Federico IIMauro Cataldi - University of Naples Federico IIAnna Maria Colao - University of Naples Federico IIGaetano Lombardi - University of Naples Federico IILucio Annunziato - University of Naples Federico II
- Publication Details
- European journal of pharmacology, v 294(1), pp 11-15
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology; Drexel University
- Web of Science ID
- WOS:A1995TN77700002
- Scopus ID
- 2-s2.0-0029417146
- Other Identifier
- 991020099873004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy