Journal article
Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology
Neurobiology of disease, v 25(1), pp 17-26
2007
PMID: 17011204
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study sought to determine the role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology. We studied the effect of the HIV envelope protein gp120 on the expression of E2F1-dependent apoptotic proteins in human and rodent neurons and examined the expression pattern of E2F1 in the brain of HIV-infected individuals. Our findings suggest that in cultured neurons gp120 increased E2F1 levels in the nucleus, stimulated its transcriptional activity and enhanced the expression of the E2F1 target proteins Cdc2 and Puma. Studies with neuronal cultures from
E2F1 deficient mice demonstrated that the transcription factor is required for gp120-induced neurotoxicity and up-regulation of Cdc2 and Puma. Levels of E2F1 protein were greater in the nucleus of neurons in brains of HIV-infected patients exhibiting dementia when compared to HIV-negative subjects or HIV-positive neurologically normal patients. Overall, these studies indicate that E2F1 is primarily involved in CXCR4-mediated neurotoxicity and HIV neuropathogenesis.
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Details
- Title
- Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology
- Creators
- Saori Shimizu - Department of Pharmacology and Physiology, Drexel University, College of Medicine, 245 North 15th Street, NCB 8804, Philadelphia, PA 19102, USAMuhammad Z Khan - Department of Pharmacology and Physiology, Drexel University, College of Medicine, 245 North 15th Street, NCB 8804, Philadelphia, PA 19102, USARandi L Hippensteel - Department of Pharmacology and Physiology, Drexel University, College of Medicine, 245 North 15th Street, NCB 8804, Philadelphia, PA 19102, USAAnjum Parkar - Department of Pharmacology and Physiology, Drexel University, College of Medicine, 245 North 15th Street, NCB 8804, Philadelphia, PA 19102, USARamesh Raghupathi - Department of Neurobiology and Anatomy, Drexel University, College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USAOlimpia Meucci - Department of Pharmacology and Physiology, Drexel University, College of Medicine, 245 North 15th Street, NCB 8804, Philadelphia, PA 19102, USA
- Publication Details
- Neurobiology of disease, v 25(1), pp 17-26
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Pharmacology and Physiology
- Web of Science ID
- WOS:000242665200003
- Scopus ID
- 2-s2.0-33751081286
- Other Identifier
- 991014878245104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences